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Typical concentrations: 0.25 mg pen: 0.68 mg/mL 0.5 mg pen: 1.34 mg/mL (some packs 0.68 mg/mL in 3 mL) 1.0 mg pen: 1.34 mg/mL 1.7 mg pen: 2.27 mg/mL 2.4 mg pen: 3.2 mg/mL Therefore: 0.01 mL dose concentration , e.g., on the 2.4 mg pen (3.2 mg/mL) , 1 click 0.032 mg

Roughly half of all survivors are left with permanent neurological damage, according to a 2022 meta-analysis in Contrast Media and Molecular Imaging

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The REDEFINE 3 cardiovascular outcomes trial which will take several years to complete is not a prerequisite for initial market authorisation for obesity treatment, but its results will likely be important for subsequent label expansion and for establishing the cardiovascular benefit profile that has proven so valuable for tirzepatide and semaglutide